The Effect of Standard vs. Shorter Filter Lifespan During Continuous Renal Replacement Therapy

Own data of patients under standard care indicated that a longer filter lifetime in CRRT is associated with an increased rate of new infections.

The aim of this study is to demonstrate that a protocolized filter-change strategy can be reliably implemented in critically ill patients and a high protocol adherence can be achieved.

The secondary aim is to investigate whether a shorter filter-change strategy is be associated with a lower incidence of newly acquired infections.

Inclusion criteria

• Adult ≥ 18 years
• Critically ill patients with severe AKI consistent with KDIGO stage 3 and an absolute indication for CRRT
• Written consent form from the patient or legal representative or authorized representative or emergency inclusion

Exclusion criteria

• End-stage kidney disease or chronic dialysis dependence
• Chronic kidney disease with eGFR<20ml/min/1.73 m²
• Prior kidney transplant
• Prior renal replacement therapy during the index admission before randomization
• Glomerulonephritis, interstitial nephritis, vasculitis
• Patients on immunosuppression (above the cushing threshold)
• Patients with chronic inflammatory diseases (e.g. arthritis, HIV with a CD4 count of < 0.05 x 10E/l)
• Do-not resuscitate order
• Persons with any kind of dependency on the investigator or employed by the sponsor
• Patients participating in an interventional study involving measures to influence the immune system