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Completed

NCT Number: NCT04596969

The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite

This study examines the effect of soluble fiber dextrin on food intake, appetite, and physiological markers of appetite. Adults aged 18-45 years with a BMI were recruited for this study. Participants were given two doses of SFD in the morning and appetite, food intake and physiological markers of appetite were measured over 10 years.

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Key information

Conditions

Appetitive Behavior Behavior Behavior, Animal

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Overweight and obesity are leading health problems. The study investigates the effect of a food ingredient from two different sources at two different doses on food intake and appetite markers over a 10 hour period. All participants reported to the laboratory first thing in the morning and remained in the laboratory until after their evening meal. A fixed breakfast was served but the participants were free to eat as much as they liked at lunch and dinner. Blood was taken at regular intervals during the day and assayed for glucose and several hormones related to appetite. Subjective measures of appetite were also collected over the 10 hour test session.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI 19.9 - 29.9 Aged 18-45 Find the study foods to be palatable

Exclusion criteria

Weight change > 3kg in the past three months Do not regularly consume snacks Presence or history of GI disorders Restrained eater Used medication that influences appetite

Treatment and study plan

Soluble Fiber Dextrin

Other

Ingredient based on resistant starch

Primary outcomes

  1. Food intake

    Time frame: 10 hours

    Food intake measured at lunch and evening meal.

Secondary outcomes

  1. Appetite

    Time frame: 10 hours

    Subjective appetite measures using questionnaires at regular intervals over 10 hours,

  2. CCK

    Time frame: 10 hours

    Plasma CCK measured at regular intervals over 10 hours.

  3. GLP-1

    Time frame: 10 hours

    Plasma GLP-1 measured at regular intervals over 10 hours.

  4. PYY3-36

    Time frame: 10 hours

    Plasma PYY3-36 measured at regular intervals over 10 hours.

  5. Breath Hydrogen

    Time frame: 10 hours

    Breath hydrogen measured at regular intervals over 10 hours.

Sponsors and collaborators

Lead sponsor

Iowa State University

Other

Registry information

Official study title

The Effect of Soluble Fiber Dextrin on Subjective and Physiological Markers of Appetite: a Randomized Trial

Important dates

Study start
2014
Primary completion
2017
Study completion
2018
First posted
Oct 22, 2020
Registry last updated
Oct 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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