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NCT Number: NCT07637331

The Effect of Respiratory Muscle Training on Cognitive Performance

Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.

Recruiting

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Key information

Conditions

Respiratory Muscle Training

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Indiana University

Bloomington, Indiana, 47405, United States

Location status: Recruiting

Location contact

Blair Johnson, PhD

CONTACT

[email protected]

812-855-8699

Blair Johnson, PhD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-40 years old
  • Body mass index <30 kg/m2
  • Naïve to IMT
  • >75% of predicted forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC) (FEV1/FVC)
  • Access to smart phone or tablet with internet

Exclusion criteria

  • Diagnosed:
  • Cardiovascular disease
  • Respiratory disease (including asthma)
  • Metabolic disease
  • Currently pregnant
  • Unable to adhere to the IMT protocol
  • Answering 'yes' to any of the questions on page one of the PAR-Q+
  • Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)
  • Self-reported color blindness
  • Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study

Treatment and study plan

Inspiratory muscle training

Device

8 weeks of active or sham inspiratory muscle training

Primary outcomes

  1. Diaphragm thickness

    Time frame: Baseline and after 8 weeks of training

    ultrasound measurements of diaphragm thickness

  2. Cognitive performance

    Time frame: Baseline and after 8 weeks of training

    CAAPES performance with the higher percentage correct corresponding to a better performance.

Secondary outcomes

  1. Dyspnea

    Time frame: Baseline and after 8 weeks of training

    Measure of breathing discomfort and pleasantness using a visual analog scale, the higher the value the more discomfort and unpleasant the subject's breathing is.

Study contacts

Contact information is provided by the study sponsor or research team.

Blair Johnson

CONTACT

[email protected]

812-855-8699

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Collaborators

  • United States Air Force Research Laboratory

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jun 9, 2026
Registry last updated
Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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