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Completed

NCT Number: NCT02674659

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery

This research add resistance training to patients who undergo cardiac rehabilitation program after coronary bypass surgery, comparing the level of PCSK9 level on that group to another group who receives conventional rehabilitation program (only aerobic exercise)

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Hypercholesterolemia, Autosomal Dominant, 3 Myocardial Ischemia Vascular Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The PCSK9 level measured before and after cardiac rehabilitation program (around 3-4 weeks), and compared between two groups. ELISA method will be used to measure plasma PCSK9 level.

Resistance training will be given by professional trainer in gymnasium of National Cardiovascular Center Harapan Kita supervised by cardiologists, following rules from American College of Sports Medicine guideline regarding to exercise after cardiac event.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • post elective coronary artery bypass surgery
  • > 18 years old
  • sign informed consent

Exclusion criteria

  • contraindications of resistance training (unstable angina, uncontrolled blood pressure (systolic > 160 mmHg diastolic > 100 mmHg), acute heart failure, pulmonary diseases, arrhythmia malignant)
  • musculoskeletal pain, visual analog scale >3
  • post congenital heart disease surgery
  • post elective coronary artery bypass surgery with malfunction valves (operated or not)

Treatment and study plan

Resistance training

Behavioral

resistance training consists of lower and upper extremities exercises. We focus on biceps and hamstring to be trained. One session was held for around 30 minutes.

Aerobic training

Behavioral

aerobic exercise consists of warming up session, treadmill exercise (around 20-30 minutes), and wrap-up session (for all session about 1 hour)

Primary outcomes

  1. PCSK-9 Level

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program. The method that we use to check PCSK-9 level is ELISA method

Secondary outcomes

  1. Low Density Lipoprotein

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program

  2. Body Mass Index

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    Body Mass Index is calculated by calculating the measured body weight divided by the height square in measure. We take BMI data after cardiac rehabilitation program in every participant.

  3. High-Density Lipoprotein

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program

  4. Total Cholesterol

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program

  5. Triglyceride

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    This outcome measurement will be achieved by taking the patient's blood sample after cardiac rehabilitation program

  6. Fasting Blood Glucose

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    Blood glucose concentration was taken after 10-12-hour fasting. This outcome measurement will be achieved by taking the patient's blood sample after cardiac rehabilitation program

  7. Systolic Blood Pressure

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    this outcome measurement will be achieved by taking the patient's blood pressure after cardiac rehabilitation program

  8. Diastolic Blood Pressure

    Time frame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)

    this outcome measurement will be achieved by taking the patient's blood pressure after cardiac rehabilitation program

Sponsors and collaborators

Lead sponsor

National Cardiovascular Center Harapan Kita Hospital Indonesia

Other

Registry information

Official study title

The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 (PCSK-9) Level in Patients After Coronary Bypass Surgery

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Feb 4, 2016
Registry last updated
Jan 21, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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