The Effect of Remote Ischemic Conditioning in Patients With Hypercholesterolemia

Study population:

We plan to include 12 poorly controlled/newly diagnosed subjects with familiar hypercholesterolemia (FH) and 12 age-matched control subjects.

Inclusion criteria

(FH subjects)

• Poorly treated FH, defined as LDL-C >5.5 mmol/L.
• Age, >18 and <65 years of age.

Exclusion criteria

• Additional cardiovascular comorbidities such as diabetes mellitus, coronary artery disease, or kidney failure.
• Unwillingness to participate.
• Concurrently participating in another interventional trial.

Main exposure:

Remote ischemic conditioning, i.e. 4 cycles of 5 minutes of ischemia to the lower limb.

Comparision group:

Cross over design, patients preform the protocol twice, once with sham and once with RIC. Also a group of healthy matched controls will be recruited.

Outcome:

Change in FMD after 20 minutes of ischemia and 20 minutes of reperfusion with the exposure of either sham or RIC.

Design:

Randomized interventional cross-over.

Inclusion criteria

• Poorly treated FH, defined as LDL-C >5.5 mmol/L.
• Age, >18 and <65 years of age.
• A age matched control-group.

Exclusion criteria

• Additional cardiovascular comorbidities such as diabetes mellitus, coronary artery disease, or kidney failure.
• Any condition which interfere with the outcome recording for example atrial fibrillation.
• Unwillingness to participate.
• Concurrently participating in another interventional trial.