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Completed

NCT Number: NCT02980900

The Effect of Protein Ingestion on the Recovery of Skeletal Muscle Function Following Eccentric Exercise.

The present study will assess the effect of the type and timing of protein ingestion 6 days prior to, and 7 days following eccentric exercise on the time course of 1) the recovery of muscle function, 2) the recovery of perceived muscle soreness, 3) muscle metabolism.

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Key information

Conditions

Healthy

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sport and Health Sciences

Exeter, Devon, EX1 2LU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women who are generally healthy and recreationally active

Exclusion criteria

  • Active cardiovascular disease or hypertension
  • Diagnosed metabolic impairment
  • Use of nutritional supplements
  • Use of anti-inflammatory medications
  • Habitual dietary protein intake of <0.8g/kg/day
  • Musculoskeletal disorders

Treatment and study plan

Post exercise protein-polyphenol supplement

Dietary Supplement

Participants will ingest a post exercise protein-polyphenol supplement. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Post exercise placebo supplement

Dietary Supplement

Participants will ingest an isocaloric placebo supplement after exercise. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed protein-polyphenol supplement

Dietary Supplement

Participants will ingest a protein-polyphenol supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed placebo supplement

Dietary Supplement

Participants will ingest an isocaloric placebo supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Primary outcomes

  1. Isokinetic force production of the knee extensor muscles

    Time frame: 14 days

Secondary outcomes

  1. Muscle protein synthesis

    Time frame: 14 days

  2. Thigh volume

    Time frame: 14 days

  3. Perceived muscle soreness

    Time frame: 14 days

  4. Isometric force production of the knee extensor muscles

    Time frame: 14 days

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Acronym: SPADE

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Dec 2, 2016
Registry last updated
Oct 16, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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