Skip to main content
OpenTrials
Completed

NCT Number: NCT01638624

The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury

The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.

Plasma total antioxidant capacity is a well-established marker of the overall protective effect of antioxidants in body fluids.The aim of the study is to investigate the effects of propofol on ischemia-reperfusion injury in total knee arthroplasty (TKA).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Total Knee Arthroplasty Tourniquet-Induced Ischemia-Reperfusion Injury

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Ministry of health Diskapi Yıldirim Beyazit Training and Research Hospital Anesthesiology and Biochemistry Clinics

Ankara, 06110, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II physical status
  • Unilateral total knee arthroplasty
  • Age 18 years to 80 years

Exclusion criteria

  • Severe central nervous system disorders
  • Severe cardiopulmonary,renal,metabolic, or hepatic disease,
  • Blood volume deficits,
  • Coagulopathy,
  • Allergy to local anesthetics,
  • Peripheral neuropathies,
  • Body mass index > 35,
  • History of antioxidant drug use

Treatment and study plan

Propofol

Drug

Propofol :Propofol is an anesthetic agent, has structure similar to that of known such as alfa tocopherol.

Placebo

Drug

Primary outcomes

  1. The perioperative alternation of the venous blood total antioxidant capacity levels of the arms

    Time frame: T1,T2,T3

    T1 : Before the spinal anesthesia performed T2 : At 30th min of tourniquet inflation T3 : At 2nd hours of tourniquet deflation

Sponsors and collaborators

Lead sponsor

Diskapi Teaching and Research Hospital

Other

Registry information

Official study title

The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury in Total Knee Arthroplasty

Important dates

Study start
2012
Primary completion
2012
Study completion
2012
First posted
Jul 12, 2012
Registry last updated
Jun 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.