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Completed

NCT Number: NCT02149628

The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide

Robot assisted laparoscopic radical prostatectomy(Robot-LRP) requires pneumoperitoneum and trendelenburg position which result in oxidative stress and inflammatory response.

Propofol is well known to reduce those responses during anesthesia. Therefore, we try to figure out the efficacy of propofol to reduce oxidative stress, inflammatory response and increase the nitric oxide activity during robot-LRP compared to that of desflurane.

To investigate the oxidative stress, malondialdehyde will be measured. As inflammatory markers, interleukin-1β, interleukin-6, tumor necrosis factor-α will be measured. Nitric oxide will be measured as well.

Secondarily, kidney protection effect of propofol over desflurane will be compared.

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Key information

Conditions

Prostate Cancer Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

20 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 4

Primary location

Yonsei University, Gangnam Severance Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia

Exclusion criteria

  • chronic renal failure ( estimated glomerular filtration rate <60 mL/min/1.73m2)
  • allergy to propofol, nuts
  • on diuretics, vitamin C or vitamin E within 5 days before surgery
  • Body mass index > 30 kg/m2
  • older than 70 years
  • who cannot read the patient consent form

Treatment and study plan

Propofol

Drug

Other names: fresofol, 2%

Desflurane

Drug

Primary outcomes

  1. changes of serum malondialdehyde, Interleukin-1β, interleukin-6, tumor necrotic factor-α, nitric oxide during operation

    Time frame: 100 min after pneumoperitoneum, 10 min after decompression

Secondary outcomes

  1. kidney function after anesthesia

    Time frame: 1 day after operation

    measure creatinine

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Official study title

The Effect of Propofol Based Total Intravenous Anesthesia on Oxidative Stress and Nitric Oxide in Patients Undergoing Laparoscopic Surgery

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
May 29, 2014
Registry last updated
Jul 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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