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OpenTrials
Completed

NCT Number: NCT04144114

The Effect of ProHydrolase® on the Amino Acid, Intramuscular Anabolic Signaling, and Endocrine Response to Resistance Exercise in Trained Males

To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL). To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway. To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

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Key information

Conditions

Amino Acids

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lipscomb University

Nashville, Tennessee, 37204, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • At least one-year of resistance training experience
  • Free of any physical limitations (determined by health and activity questionnaire).
  • Between the ages of 18 and 35.
  • Ability to leg press a weight equivalent to 1.5 times their body mass

Exclusion criteria

  • • Inability to perform physical exercise (determined by health and activity questionnaire)
  • Taking any other nutritional supplement or performance enhancing drug (determined from health and activity questionnaire).
  • Physical injury preventing the athlete from participating in offseason training
  • Any chronic illness that causes continuous medical care

Treatment and study plan

ProHydrolase®

Dietary Supplement

Subjects received 250mg of ProHydrolase® with 25g whey protein mixed together in a drink

Whey Protein

Dietary Supplement

Subjects received 25g of whey protein powder mixed to together in a drink

Placebo

Dietary Supplement

Placebo

Primary outcomes

  1. Amino acid absorption

    Time frame: 4 weeks

    To examine the amino acid absorption following acute resistance exercise between three supplemental treatments: 1) Whey Protein + ProHydrolase (WPH) 2) Whey Protein (W) and 3) Non-Caloric Placebo (PL)

  2. mTORC1 pathway

    Time frame: 4 weeks

    To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on the mTORC1 complex pathway

  3. Endocrine markers

    Time frame: 4 weeks

    To examine three supplemental treatments (WPH, W, PL) in conjunction with acute resistance exercise on circulating concentrations of endocrine biomarkers.

Sponsors and collaborators

Lead sponsor

Deerland Enzymes

Industry

Collaborators

  • Lipscomb University

Registry information

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Oct 30, 2019
Registry last updated
Oct 30, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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