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Enrolling by Invitation

NCT Number: NCT06985654

The Effect of Preoperative Intravenous Fluid Bolus on Post-induction Hypotension in Elective Cystoscopies.

This study aims to determine whether a standardized, weight-based crystalloid fluid bolus administered preoperatively reduces the incidence of postinduction hypotension (PIH) in patients undergoing cystoscopy.

Enrolling by Invitation

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Key information

Conditions

Postinduction Hypotension Cardiovascular Diseases Hypotension Hypotension During Surgery Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University Hospital

Columbia, Missouri, 65212, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years old.
  • Undergoing elective cystoscopy surgery as the primary procedure.
  • Able to provide informed consent.

Exclusion criteria

  • Emergency surgeries.
  • Past history of amputations of any body part.
  • Allergies or contraindications to any medications used in the protocol or lactated ringers.
  • Systolic heart failure with LVEF < 30% within the last year.
  • Severely depressed RV function within the last year.
  • Restrictive diastolic dysfunction within the last year.
  • Currently pregnant.

Treatment and study plan

Lactated Ringers

Drug

A bolus of Lactated Ringers (15mL/kg of ideal body weight) will be given to patients prior to anesthesia induction.

Primary outcomes

  1. Incidence of Postinduction Hypotension

    Time frame: From the time patient enters the operating room to the end of surgery, assessed up to 24 hours.

    Number of patients that experience a decrease in mean arterial pressure (MAP) greater than 20% from the baseline MAP.

Other outcomes

  1. Inferior Vena Cava Size

    Time frame: From the time of consent to the beginning of surgery, assessed up to 24 hours.

    Size of the inferior vena cava before surgery, approximated using a point-of-care ultrasound scan

  2. Respiratory Variability

    Time frame: From the time of consent to the beginning of surgery, assessed up to 24 hours.

    Change in the size of the inferior vena cava during respiration, approximated using a point-of-care ultrasound scan

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 22, 2025
Registry last updated
Sep 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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