Division of Nutrition, University of Helsinki
Helsinki, 00790, Finland
NCT Number: NCT02469285
High consumption of red meat is related to cardiovascular diseases. Red meat containing more unsaturated fat than normal red meat may have a beneficial impact on plasma lipid and fatty acid profile in humans. Furthermore, consumption of red meat and especially processed red meat is considered harmful to colon health. However, consumption of fruit and berries rich in antioxidants and flavonoids may provide protection when red meat is consumed.
The study aims to answer whether the fatty acid profile of pork when modified towards more unsaturated fat will affect plasma fatty acids and lipids in adult volunteers. The effects of pork with a modified fatty acid content is compared with conventional pork with lower unsaturated fat content. Fatty acid composition of pork is modified by altering the composition of animal feed.
The other arm of the study investigates the effects of consuming berries together with red meat on gut metabolism. The study focuses on how berries affect the formation of fecal compounds known to be related to high red meat consumption, such as N-nitroso compounds.
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Notify Me20 year–68 year
All sexes
Interventional
Not applicable
Helsinki, 00790, Finland
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Pork with modified fatty acid composition
Other names: Pork with modified fatty acid composition and berries, Pork, Pork and Finnish berries
Pork with normal fat composition
Pork with normal fat composition and Finnish berries
Time frame: 4 weeks
Time frame: 4 weeks
Measured as apparent total nitroso compounds (ATNC)
Time frame: 4 weeks
Fecal water is isolated from fecal samples collected before and after the intervention period from arms B and C. The samples are tested for markers of genotoxicity in 3D cell culture.
Time frame: 4 weeks
Concentrations of and changes in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides are measured before and after the intervention period
Time frame: 4 weeks
The polyphenol content of the fecal water is assessed from arms B and C
Time frame: 4 weeks
Time frame: 4 weeks
Blood pressure is measured before and after the study period.
Time frame: 4 weeks
The subjects are weighed before and after the study and their weight is monitored weekly during the study
University of Helsinki
Other
The Effect of Pork With Modified Fatty Acid Composition on Plasma Lipids and Fatty Acids and the Effect of Pork and Berries on Fecal Compounds in Healthy Adults
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