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NCT Number: NCT04840511

The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping

This study will be done to investigate perioperative lidocaine infusion on neutrophil extracellular trapping in the patients undergoing the robot-assisted prostatectomy.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Urologic Cancer Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Neoplasms Neoplasms by Site Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

20 year–75 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Seoul St.Mary's Hospital

Seoul, Seocho-gu, 07651, South Korea

About this study

Neutrophil extracellular trapping by analyzing the meyloperoxidase, neutrophil elastase, citrullinated histone3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients scheduled robot-assisted prostatectomy

Exclusion criteria

  • lidocaine allergy Hx
  • hemodynamic unstable patients
  • weight < 40kg
  • arrhythmia or bradycardia

Treatment and study plan

Lidocaine group

Drug

lidocaine 1.5 mg/kg bolus (infused over 10 min) followed by 2.0 mg/kg/h during operation and 1.0 mg/kg/h during postoperative 24 hours (no more than 120 mg/h)

Other names: lidocaine

Control group

Drug

normal saline 0.15 ml bolus followed by 0.2 ml/kg/hr during operation and 0.1 ml/kg/hr during postoperative 24 hours

Other names: normal saline

Primary outcomes

  1. Concentration of citrullinated histone3

    Time frame: 24 hours after surgery

    This will be obtained using ELISA.

Secondary outcomes

  1. Concentration of meyloperoxidase

    Time frame: 24 hours after surgery

    This will be obtained using ELISA.

  2. Concentration of neutrophil elastase

    Time frame: 24 hours after surgery

    This will be obtained using ELISA.

Other outcomes

  1. the severity of postoperative pain using NRS

    Time frame: during postoperative 24 hours

    This will be measured using NRS (numeric rating scale; 0=no pain, 10=the worst pain)

Sponsors and collaborators

Lead sponsor

The Catholic University of Korea

Other

Registry information

Official study title

The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular Trapping in the Patients Undergoing the Robot-assisted Prostatectomy

Important dates

Study start
2021
Primary completion
2022
Study completion
2027
First posted
Apr 12, 2021
Registry last updated
Jan 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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