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NCT Number: NCT07140991

The Effect of Perioperative Hyperglycemia on Anastomotic Leaks After Total Gastrectomy

Esophagojejunostomy anastomosis is used in total gastrectomy surgeries. Anastomotic leakage is a serious complication seen after these surgeries and is associated with increased morbidity and mortality. Patients with older age and comorbidities have a higher risk of death following anastomotic leakage.

Perioperative hyperglycemia is frequently observed in patients undergoing major abdominal surgery as a stress response to surgical trauma, leading to surgical complications through mechanisms such as glycogenolysis, lipolysis, gluconeogenesis, decreased insulin sensitivity, and increased insulin resistance. Hyperglycemia is known to increase the risk of postoperative infection, prolong hospital stay, and increase mortality. Additionally, recent studies have shown that it also increases the risk of anastomotic leakage.

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Key information

Conditions

Hyperglycaemia Anastomotic Leak Anastomotic Leaks Glucose Metabolism Disorders Hyperglycemia Metabolic Diseases Nutritional and Metabolic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Total Gastrectomy

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Basaksehir Cam ve Sakura City Hospital

Istanbul, Turkey (Türkiye)

About this study

Although diabetes mellitus is a known risk factor for anastomotic leaks, there are few studies on the relationship between perioperative hyperglycemia and anastomotic leaks. The primary objective of our study was to demonstrate the relationship between hyperglycemia detected during anastomosis formation in the perioperative period and postoperative anastomotic leaks.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • elective total gastrectomy
  • anastomotic leak after surgery
  • age 18-75

Exclusion criteria

  • emergency procedure
  • <18 years
  • >75 years
  • ASA score > 3

Treatment and study plan

Primary outcomes

  1. postoperative anastomotic leakage

    Time frame: 30 days after surgery

    Patients who developed anastomotic leak after total gastrectomy

Secondary outcomes

  1. diabetic hyperglysemia

    Time frame: intraoperative

    Patients with diabetes but unregulated blood sugar

  2. non-diabetic hyperglysemia

    Time frame: intraoperative

    Patients without diabetes who became hyperglycemic due to surgical stress

Sponsors and collaborators

Lead sponsor

Taner Abdullah

Other

Registry information

Official study title

The Effect of Perioperative Hyperglycemia on Anastomotic Leaks in Patients Undergoing Total Gastrectomy: A Retrospective Cohort Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 26, 2025
Registry last updated
Aug 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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