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Completed

NCT Number: NCT03939936

The Effect of Periodontal Treatment on Psoriasis

There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

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Key information

Conditions

Periodontal Diseases Mouth Diseases Psoriasis Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gaziosmanpasa University

Tokat Province, 60250, Turkey (Türkiye)

About this study

The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • the presence at least 20 remaining teeth,
  • the presence of Stage I or Stage II Periodontitis,
  • the presence of diagnosed psoriasis.

Exclusion criteria

  • patients who had the immune-inflammatory disease and require antibiotic prophylaxis,
  • patients who received periodontal treatment prior to 6 months,
  • women who were breastfeeding or pregnant,
  • patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.

Treatment and study plan

Psoriatic measurements

Other

Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Non-surgical periodontal treatment

Other

Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Saliva Samples

Other

Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Primary outcomes

  1. Proinflammatory cytokines

    Time frame: Baseline and after 8 weeks

    The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment.

Secondary outcomes

  1. Gingival index

    Time frame: Baseline and after 8 weeks

    The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.

  2. PASI index

    Time frame: Baseline and after 8 weeks

    The changes in PASI index level after periodontal treatment. PASI index was measured for determining the severity of psoriasis disease. Higher values represent a worse outcome. After periodontal treatment, a reduction in PASI index value is expected.

Sponsors and collaborators

Lead sponsor

Ozge Gokturk

Other

Registry information

Official study title

Effects of Non-surgical Periodontal Therapy on Inflammatory Markers of Psoriasis

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 7, 2019
Registry last updated
May 9, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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