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Completed

NCT Number: NCT03031405

The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories

The purpose of the study is to examine whether oxytocin and oxytocin receptor gene polymorphism affect the development of intrusive memories, a cardinal symptom of PTSD.

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Key information

Conditions

Intrusive Memories

Age range

18 year–44 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Charité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin

Berlin, 12203, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy female volunteers
  • German on a native level

Exclusion criteria

  • former or present disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5)
  • any physical illnesses
  • any medication intake (except oral contraceptive)
  • history of traumatic experience, e.g. history of sexual abuse or rape
  • pregnancy or lactation period
  • follicular phase of menstrual cycle for all women not using oral contraceptives

Treatment and study plan

Oxytocin nasal spray

Drug

Placebos

Drug

Placebo nasal spray

Primary outcomes

  1. Intrusive memories

    Time frame: four consecutive days

    Influence of oxytocin on the development of intrusive memories measured with an intrusion diary

Secondary outcomes

  1. Noradrenergic System (measured with salivary alpha-amylase - u/ml)

    Time frame: Day 1

    Influence of oxytocin on the noradrenergic system measured with salivary alpha-amylase

  2. Genetic polymorphism

    Time frame: four consecutive days

    Influence of genetic polymorphism of the oxytocin receptor on intrusive memories measured with an intrusion diary

  3. Hypothalamic-pituitary-adrenal (HPA) axis (measured with salivary cortisol - nmol/L)

    Time frame: Day 1

    Influence of oxytocin on the HPA-axis measured with salivary cortisol

Sponsors and collaborators

Lead sponsor

Charite University, Berlin, Germany

Other

Collaborators

  • Central Institute of Mental Health, Mannheim

Registry information

Official study title

The Effect of Oxytocin on the Acquisition and Consolidation of Trauma-Associated Memories: A Model to Understand the Development of Posttraumatic Stress Disorder

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jan 25, 2017
Registry last updated
Aug 21, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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