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NCT Number: NCT06045611

The Effect of Oral Intake of Animal and Plant Proteins on the Metabolism in Healthy Women

The goal of this interventional study is to learn about the effects of different proteins (from animals or plants) on the metabolism in healthy, normal weight women between 18-45 year who are not on hormonal birth-control.

The main questions the study aims to answer are:

1. How do different proteins affect biological markers of the metabolism and which protein has the strongest effect? 2. How are the different proteins digested and taken up from our body?

Participants will drink four different shakes on four different study days in a random order. Three of them contain each a different protein and one does not contain protein. Right before drinking the shake and on 11 timepoints after drinking the shake blood samples will be drawn.

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Key information

Conditions

Healthy

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Örebro University

Örebro, 70182, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Females
  • Age: 18-45 years
  • Body mass index: 18.5 < 25 kg/m2
  • Signed informed consent

Exclusion criteria

  • Use of hormonal contraceptives
  • Pregnancy or breastfeeding
  • Diabetes mellitus or any other metabolic disease that might affect the results of this study
  • Gastric surgery that affects digestion and uptake of protein
  • Any clinically significant present or past disease/condition and medication which in the investigator's opinion could interfere with the results of the trial

Treatment and study plan

Isolated Pea Protein

Dietary Supplement

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Whey Protein

Dietary Supplement

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Isolated Faba Bean Protein

Dietary Supplement

Participants will consume the protein supplement dissolved in water in an opaque mug wearing a nose clip.

Placebo

Dietary Supplement

Participants will consume the placebo in an opaque mug wearing a nose clip.

Primary outcomes

  1. Release of Growth Hormone

    Time frame: 0-3 hours after consumption of test drink (on all 4 study days)

    The primary outcome is defined as the postprandial release of growth hormone during three hours after oral ingestion of plant-protein test drinks vs. an animal-protein test drink measured as incremental area under the curve. Growth hormone will be measured in blood samples.

Secondary outcomes

  1. Release of Hormones Related to the Somatotrophic Axis

    Time frame: 0-3 hours after consumption of test drink (on all 4 study days)

    We will measure different hormones related to the somatotrophin axis in collected blood samples and investigate if there are differences between different protein-sources.

  2. Kinetics of Amino Acid Uptake

    Time frame: 0-3 hours after consumption of test drink (on all 4 study days)

    We will measure amino acids in collected blood samples to investigate dynamics and kinetics of protein digestion/uptake of different protein sources.

Sponsors and collaborators

Lead sponsor

Örebro University, Sweden

Other

Registry information

Official study title

The Effect of Oral Ingestion of Animal and Plant-based Proteins on the Somatotropic Axis

Acronym: PAN-Promet

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Sep 21, 2023
Registry last updated
Jun 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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