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NCT Number: NCT07374055

The Effect of Nutritional Status on Postoperative Mortality and Morbidity in the Geriatric Population Undergoing Gastrointestinal Surgery

The purpose of this study was to compare the sensitivity and specificity of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment Scale-Short Form (mNA-SF) and Systemic Immune-Inflammatory Index (SII) values calculated in the preoperative evaluation in patients over 65 years of age who underwent gastrointestinal surgery, in predicting morbidity and mortality in the postoperative period.

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Key information

Conditions

Nutrition Assessment Geriatric Anesthesia

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Kartal Dr. Lutfi Kirdar City Hospital

Istanbul, Kartal, 34890, Turkey (Türkiye)

About this study

It is crucial to evaluate the impact of nutritional status and systemic inflammation markers on postoperative outcomes in geriatric patients undergoing gastrointestinal surgery.

Nutritional status has a decisive impact on the development of morbidity and mortality in geriatric patients. The risk of malnutrition is particularly high in the geriatric patient population undergoing gastrointestinal surgery. Predicting postoperative outcomes in these patient groups is becoming increasingly important. To this end, many different risk scoring systems have been developed.

Low nutritional scores and increased inflammatory responses are associated with high mortality, prolonged hospitalization and intensive care unit stays, and complications. The primary goal of preoperative risk scoring is to predict potential complications before, during, and after surgery, and to minimize risks and mortality by attempting to prevent them.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled to undergo gastrointestinal surgery.

Age 65 years and older.

ASA (American Society of Anesthesiologists) physical status class 3 or 4.

Mini-Mental State Examination (MMSE) score of 21 or higher

Exclusion criteria

  • Patients who do not consent to participate in the study.

Patients with acute infection during the preoperative period.

Patients who received albumin replacement in the preoperative period.

Patients with a Mini-Mental State Examination (MMSE) score below 21.

Treatment and study plan

Preoperative Risk Scoring

Other

Patients will be evaluated preoperatively using three distinct scoring systems: the Geriatric Nutritional Risk Index (GNRI), the Mini Nutritional Assessment-Short Form (mNA-SF), and the Systemic Immune-Inflammation Index (SII). These scores are calculated based on serum albumin levels, body weight, a 6-question survey, and laboratory values (platelets, neutrophils, and lymphocytes).

Postoperative Morbidite and Mortality Monitoring

Other

Systematic tracking of postoperative outcomes including hospital and ICU stay duration, pulmonary complications (e.g., pneumonia, embolism), extrapulmonary complications (e.g., surgical site infection, organ failure, delirium), and mortality rates at 30, 60, and 90 days.

Delirium Assessment Protocol

Other

Patients will be monitored for delirium preoperatively, on the first postoperative day, and before discharge using the Confusion Assessment Method (CAM/CAM-ICU) and the Richmond Agitation-Sedation Scale (RASS).

Primary outcomes

  1. Systemic Immune-Inflammation Index (SII)

    Time frame: Preoperative (Baseline)

    Calculated as (Platelets x Neutrophils) / Lymphocytes from preoperative blood samples.The unit of measure is cells per microliter.

  2. Geriatric Nutritional Risk Index (GNRI) as a predictor of postoperative complications

    Time frame: Preoperative (Baseline)

    GNRI will be calculated using serum albumin and body weight. Scores will be used to categorize patients' nutritional risk.Units on a scale of 0 to 120, where lower scores indicate higher nutritional risk.

  3. Mini Nutritional Assessment-Short Form (mNA-SF) score

    Time frame: Preoperative (Baseline)

    A 6-question survey to screen for malnutrition.Measured on a scale of 0 to 14 points, where 0-7 indicates malnourishment.

Secondary outcomes

  1. Postoperative Morbidity

    Time frame: Up to 30 days post-surgery

    Monitoring of pulmonary (e.g., pneumonia, embolism) and extrapulmonary (e.g., surgical site infection, organ failure, anastomosis leak) complications

  2. Incidence of Delirium

    Time frame: Preoperative to discharge

    Assessment of delirium using the Confusion Assessment Method (CAM/CAM-ICU) and Richmond Agitation-Sedation Scale (RASS).

  3. Length of Hospital and ICU Stay

    Time frame: Total duration of hospitalization

    Recording the number of days spent in the hospital and intensive care unit.

  4. Postoperative Mortality Rate

    Time frame: 30, 60, and 90 days post-surgery

    Tracking patient survival rates at specified intervals after the operation.

Sponsors and collaborators

Lead sponsor

Dr. Lutfi Kirdar Kartal Training and Research Hospital

Other Gov

Registry information

Official study title

Effects of the Geriatric Nutritional Risk Index (GNRI), Mini Nutritional Assessment-Short Form (mNA-SF), and Systemic Immune-Inflammation Index (SII) on Postoperative Morbidity and Mortality in Geriatric Patients Undergoing Gastrointestinal Surgery

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jan 28, 2026
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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