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NCT Number: NCT06860308

The Effect of Norepinephrine on the Development of Pressure Injury

Norepinephrine mainly increases mean arterial pressure among intensive care patients. It may be an essential risk factor in developing pressure injuries. However, there are still conflicting findings in the literature.

This study aimed to examine the effect of norepinephrine infusion on the development of pressure injuries among patients in adult intensive care.

This retrospective and correlational study was conducted between March 2021- May 2022. The electronic patient data were obtained from 289 adult patients (Case group n=149; control group n=149) treated with and without norepinephrine in the intensive care unit, respectively. The demographic and clinical characteristics were evaluated using descriptive statistical methods (number, percentage, mean, standard deviation). A logistic regression model was established to estimate the dependent variable (development of pressure injury) with the independent variables.

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Key information

Conditions

Pressure Injury Pressure Ulcer Skin Diseases Skin Ulcer Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Koç University Hospital

Istanbul, 34010, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The sample consisted of all patients

  • over 18 years old
  • who did not have pressure injuries upon admission to the intensive care unit. Patients who received norepinephrine and received norepinephrine infusion for at least 48 hours during their stay in ICU were included in the case group (n=149), and patients who did not receive an infusion were included in the control group (n=140).

Exclusion criteria

The sample excluded of all patients

  • less than 18
  • who have pressure injuries during admission
  • who had norepinephrine infusion less than48 hours during their stay in the intensive care unit.

Treatment and study plan

Primary outcomes

  1. development of pressure injury after admission to intensive care unit until discharge

    Time frame: after admission of patients to the intensive care unit until discharge between from March 2021 to May 2022. .

    The development of pressure injuries after admission of patients to the intensive care unit until discharge between from March 2021 to May 2022. . This is a retrospective study, so there is no specific time. We specified time frame details below.

Sponsors and collaborators

Lead sponsor

Koç University

Other

Registry information

Official study title

The Determination of the Effect of Norepinephrine Infusion on the Development of Pressure Injury Among Critically Ill Patients

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 6, 2025
Registry last updated
Mar 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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