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NCT Number: NCT07526883

The Effect of Non-Surgical Periodontal Treatment on Systemic Inflammatory Markers and Lipid Profile in Young Adults With Severe Periodontitis

The goal of this clinical study was to evaluate whether non-surgical treatment for severe periodontitis (gum disease) could improve body-wide inflammation and blood fat levels in young adults with severe periodontitis. The main questions it aimed to answer were:

Did non-surgical periodontal treatment improve gum health in young adults with severe periodontitis?

Did non-surgical periodontal treatment change body-wide inflammation and blood fat levels after treatment?

Researchers compared participants with severe periodontitis to healthy participants without periodontitis.

Participants with severe periodontitis:

* Received oral hygiene instructions, deep cleaning below the gumline, root surface cleaning, and removal of teeth that could not be saved * Had full-mouth gum examinations * Provided blood samples at the start of the study and again at 2 and 6 months after treatment

Healthy participants:

* Had gum examinations * Provided blood samples for comparison at the start of the study

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Key information

Conditions

Periodontitis, Aggressive Aggressive Periodontitis Inflammation Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

19 year–36 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul University, Faculty of Dentistry, Department of Periodontology

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young adults aged 19 to 36 years
  • At least 20 teeth present
  • Clinical attachment loss of at least 5 mm affecting at least 8 teeth
  • Bone loss around at least 3 teeth other than incisors and first molars

Exclusion criteria

  • Systemic disease
  • Pregnancy or lactation
  • Current or former smoking
  • Systemic conditions that could alter the host response
  • Medical conditions requiring antibiotic prophylaxis during routine dental procedures
  • Antibiotic therapy within the previous 6 months
  • Previous periodontal treatment

Treatment and study plan

Non-surgical periodontal treatment

Procedure

Non-surgical periodontal treatment consisted of oral hygiene instruction, subgingival scaling, root planing, and extraction of unsalvageable teeth under local anesthesia. Treatment was completed within 1 week. Clinical periodontal measurements and blood samples were obtained at baseline and repeated at 2 and 6 months after completion of treatment.

Primary outcomes

  1. The change in serum high-sensitivity C-reactive protein (hs-CRP) concentration after periodontal treatment

    Time frame: 6 months

    This change is measured in serum, as mg/dl, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. The study was powered on the change in this parameter from baseline to 6 months after treatment.

  2. The change in HDL cholesterol concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  3. The change in LDL cholesterol concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  4. The change in total cholesterol concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  5. The change in triglyceride concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  6. The change in albumin concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  7. The change in von Willebrand factor (vWf) level after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  8. The change in creatinine concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  9. The change in fibrinogen concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as mg/dL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  10. The change in Factor VII level after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  11. The change in interleukin-1 receptor (IL-1ra) antagonist concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  12. The change in interleukin-6 (IL-6) level after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  13. The change in soluble tumor necrosis factor receptor I (sTNFRI) concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  14. The change in soluble tumor necrosis factor receptor II concentration (sTNFRII) after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as pg/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

  15. The change in tissue plasminogen activator (tPA) concentration after periodontal treatment

    Time frame: 6 months

    This parameter is measured in blood samples, as ng/mL, recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the systemic biomarker panel examined to characterize the systemic inflammatory and metabolic profile of the study participants.

Secondary outcomes

  1. The change in sulcus bleeding index (SBI) after periodontal treatment

    Time frame: 6 months

    This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.

  2. The change in plaque index (PI) after periodontal treatment

    Time frame: 6 months

    This parameter is measured by clinical examination, as a percentage (%), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.

  3. The change in clinical attachment level (CAL) after periodontal treatment

    Time frame: 6 months

    This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.

  4. The change in probing pocket depth (PPD) after periodontal treatment

    Time frame: 6 months

    This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.

  5. The change in level of gingival margin (LGM) after periodontal treatment

    Time frame: 6 months

    This parameter is measured by clinical examination, in millimeters (mm), recorded at baseline, 2 and 6 months after non-surgical periodontal treatment. It is part of the clinical periodontal parameters recorded to characterize the periodontal status of the study participants.

Sponsors and collaborators

Lead sponsor

Istanbul University

Other

Registry information

Important dates

Study start
2006
Primary completion
2009
Study completion
2010
First posted
Apr 13, 2026
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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