The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

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Key information

Conditions

End Stage Renal Disease Arterial Stiffness Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult dialysis patients
able to perform home nocturnal haemodialysis

Exclusion criteria

age < 18 and > 80 years
any patient who is anticipating a live renal transplantation in forthcoming 12 months

Treatment and study plan

Nocturnal Hemodialysis

Procedure

Primary outcomes

To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis.

Time frame: 12 months

Secondary outcomes

To examine the relationship between arterial stiffness and clinical and biochemical parameters

Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Melbourne Health

Other

Registry information

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Mar 24, 2008
Registry last updated: Apr 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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