The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.

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Key information

Conditions

Healthy Subjects

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy adult patients undergoing hypotensive anesthesia

Exclusion criteria

patients with any co-morbidity

Treatment and study plan

nicardipine

Drug

Remifentanil

Drug

0.1-0.5 ugkg/min during hypotensive anesthesia

Other names: ultiva®

Primary outcomes

Creatinine Clearance

Time frame: 2hr after the start of hypotensive anesthesia

Hypotensive anesthesia means that we maintain the mean blood pressure between 55 & 65 mmHg during surgery to decrease the blood loss.

The specific time point is exactly 2hr after we star to lower the blood pressure.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Aug 5, 2010
Registry last updated: Jun 13, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed