The Effect of Nandrolone Decanoate and Leucine on Muscle Loss

Inclusion criteria

• Healthy men 18-35 years
• BMI between 18.5 and 30 kg/m2

Exclusion criteria

• (Family) history of thromboembolic events

• Smoking
• Recent surgery (within 6 months prior to the study)
• Performing progressive resistance training more than three times per week in the past year
• Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
• Current systemic use of corticosteroids, anabolic steroids, growth hormone, testosterone, nandrolone, protein supplements, immunosuppressants or insulin, blood sugar decreasing medication or EPO
• All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
• Use of anti-coagulants
• Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)
• Liver disease
• Heart failure
• Migraine
• Allergy to nuts or soy
• High blood pressure (>140 mmHg systolic and >90 mmHg diastolic) In case of doubt, in- or exclusion of subject will be discussed with responsible physician or principal investigator.