The Effect of Midazolam Premedication on Copeptine Concentration in Blood

The study aim is to assess whether premedication with midazolam prior to surgery affects copeptin concentration in blood.

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Key information

Conditions

Preanesthetic Medication Copeptin Diabetes Insipidus Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pituitary Diseases Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

I Department of Anesthesiology and Intensive Care Medical University of Warsaw

Warsaw, Masovian Voivodeship, 02-005, Poland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients scheduled for elective surgery
Patients with no chronić illness and considered ASA 1 by anesthesiologist
Patients with mild and controlled chronic illness considered ASA 2 by anesthesiologist

Exclusion criteria

Patient refusal
Chronic illness requiring intense treatment or uncontrolled illness (ASA 3 or more)

Treatment and study plan

Midazolam Oral Tablet

Drug

Midazolam Oral tablet

Placebo Oral Tablet

Other

Glucose 1000mg tablet night before surgery and 60 minutes before surgery

Primary outcomes

Change in copeptin concentration

Time frame: 48 hours

Change in the concentration of copeptine measured in blood serum

Sponsors and collaborators

Lead sponsor

Medical University of Warsaw

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Mar 23, 2018
Registry last updated: Apr 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed