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Completed

NCT Number: NCT06268678

The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis

The combination of dietary protein ingestion and resistance exercise are essential to increase muscle protein synthesis. The vast majority of studies assessing protein intake following resistance exercise in young adults has been conducted exclusively in men or in studies where both men and women are assessed. The increase in muscle mass is thought to be impacted by sex hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis following exercise is not known.

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Key information

Conditions

Menstrual Cycle Phase Muscle Protein Synthesis

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University of Exeter

Exeter, Devon, EX1 2LT, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female, aged 18-40 years
  • BMI between 18 and 30 kg/m2
  • Recreationally active
  • Regular menstrual cycle

Exclusion criteria

  • Smoking or use of tobacco containing products
  • Irregular menstrual cycle
  • Currently on any form of hormonal contraception
  • Post-menopausal
  • Pregnant or breastfeeding
  • Diagnosed metabolic/pulmonary/musculoskeletal illness
  • Diagnosed cardiovascular disease or hypertension
  • Use of medications that may impact protein metabolism or are anti-inflammatory
  • Gastrointestinal disorders
  • Allergy to pomegranate or amino acids
  • Injuries that would impact ability to complete study

Treatment and study plan

Phase of the menstrual cycle

Other

Follicular or luteal phase

Primary outcomes

  1. Muscle protein synthesis

    Time frame: 7 hours

    The rate of synthesis of new muscle protein

Secondary outcomes

  1. Plasma amino acid kinetics

    Time frame: 7 hours

    The appearance of amino acids in the circulation.

  2. Serum insulin concentrations

    Time frame: 7 hours

    Basal and postprandial concentrations of serum insulin

  3. Sex hormone concentrations

    Time frame: 5 minutes

    Serum oestrogen and progesterone

  4. Energy expenditure

    Time frame: 20 minutes

    Basal metabolic rate

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Collaborators

  • Pvolve

Registry information

Official study title

The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis Following Protein Ingestion and Resistance Exercise in Young Women

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Feb 20, 2024
Registry last updated
Nov 15, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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