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NCT Number: NCT03161977

The Effect of Mannitol on the Serum Potassium During Craniotomy

This is an observational study designed to research the effect of mannitol on the concentration of intraoperative serum potassium in patients undergoing craniotomy, and to guide the safe use of mannitol during craniotomy.

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Key information

Conditions

Mannitol Adverse Reaction Hyperkalemia Metabolic Diseases Nutritional and Metabolic Diseases Water-Electrolyte Imbalance

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221000, China

About this study

Patients were assigned to receive 20% mannitol (1g/kg) solution administered intravenously 15-20 minutes at the time of drilling skull.The serum potassium was measured by arterial blood gas analysis before infusion (T0), infusion finished (T1), 15min (T2), 30min (T3), 60min (T4) and 120min (T5) after infusion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 18 to 70
  • American Society of Anesthesiologists physical status I to II
  • liver and kidney function is normal
  • preoperative concentration of serum potassium was from 3.5 to 5.5 mmol/L

Exclusion criteria

  • history or presence of congestive heart failure (New York Heart Association class III to IV)
  • history or presence of renal failure(diabetes insipidus, or syndrome of inappropriate antidiuretic hormone secretion)
  • intraoperative blood transfusion

Treatment and study plan

mannitol

Other

Mannitol was intravenous infused within 15-20 mins when drilling skull

Primary outcomes

  1. the concentration of serum potassium

    Time frame: two hours within infusioning mannitol

    measured by arterial blood gas analysis

Sponsors and collaborators

Lead sponsor

The Affiliated Hospital of Xuzhou Medical University

Other

Registry information

Official study title

The Effect of Mannitol on Intraoperative Serum Potassium in Patients Undergoing Craniotomy：an Observational Study

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
May 22, 2017
Registry last updated
Jul 31, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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