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OpenTrials
Completed

NCT Number: NCT04278495

The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney

Previous experimental studies concluded that angiotensin receptor blockers can ameliorate the harmful inflammatory and histological changes after relief of obstruction. Nevertheless, these witnessed effects have not been yet translated into the clinical practice.

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Key information

Conditions

Losartan Adverse Reaction Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Urogenital Diseases Urologic Diseases Uropathy Uropathy Obstructive

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Urology and nephrology center

Al Mansurah, Outside U.S./Canada, 35516, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • anuric and oliguric patients
  • calculuar ureteral obstruction

Exclusion criteria

  • anomalous kidney
  • bilateral obstructed kidney
  • history of recent use of angiotensin receptor blockers or angiotensin-converting enzyme inhibitors
  • ASA score of >3

Treatment and study plan

Cozaar (Losartan Potassium 25mg)

Drug

Cozaar (Losartan Potassium 25mg)

Other names: Cozaar

Placebo

Drug

Placebo

Primary outcomes

  1. Renographic glomerular filtration rate of the affected kidney.

    Time frame: 3 months

    assessed by radioisotope renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) in ml/min

Secondary outcomes

  1. Serum creatinine change

    Time frame: 3 months

    assessed by serum creatnine in mg/dl

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed Kidney: A Double Blind Randomized Placebo-controlled Trial

Important dates

Study start
2014
Primary completion
2018
Study completion
2018
First posted
Feb 20, 2020
Registry last updated
Feb 20, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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