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OpenTrials
Completed

NCT Number: NCT04235231

The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography

Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.

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Key information

Conditions

Lung Collapse Consciousness Disorders Lung Diseases Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Pulmonary Atelectasis Respiratory Tract Diseases Signs and Symptoms Unconsciousness

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Regional Hospital Liberec

Liberec, 46010, Czechia

About this study

In the monocentric, intervention, prospective, randomized study, the investigators will examine the effect of lateral tilting (routinely used in critical care) on the lung inhomogeneity that will be analyzed by electrical impedance tomography (EIT) in the unconscious patients with acute primary brain disease and artificial pulmonary ventilation. Two types of lateral tilting will be compared: manual positioning of body by nurse versus the bed tilting (15° lateral tilt, original company (LINET) and product brand name (Eleganza 5).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Primary brain disease
  • Hospitalization in Neurocenter, Neurointensive Care Unit
  • Age>18 years
  • Unconsciousness
  • Artificial pulmonary ventilation

Exclusion criteria

  • Intracranial hypertension
  • History of primary lung disease
  • The terminal stage of the disease
  • Refractory hemodynamic instability

Treatment and study plan

Bed tilting

Device

15° lateral tilt, original product brand name LINET Eleganza 5

Body positioning

Other

Manual positioning of body by nurse: left side, back, right side, using positioning pillows

Other names: Manual positioning of body by nurse

Primary outcomes

  1. Atelectasis/collapse

    Time frame: up to 24 weeks

    Assessed by electrical impedance tomography (EIT) or chest x-ray (CXR) at end of observation period

Secondary outcomes

  1. Evaluating oxygenation parameters

    Time frame: up to 24 weeks

    Oxygen saturation

  2. Evaluating hemodynamic parameters

    Time frame: up to 24 weeks

    Hemodynamic monitoring: stroke volume variation (SVV)

  3. Cost effectiveness measurement between two groups

    Time frame: up to 24 weeks

    Therapeutic Intervention Scoring System (TISS)

  4. Profiling pneumonia incidence

    Time frame: up to 24 weeks

    Pneumonia score

  5. Comparing duration of stay in Neurocenter Neurointensive Care Unit

    Time frame: up to 24 weeks

    Days of hospitalization

Sponsors and collaborators

Lead sponsor

Regional Hospital Liberec

Other

Collaborators

  • Charles University, Czech Republic
  • Technology Agency of the Czech Republic
  • University of Sao Paulo

Registry information

Official study title

The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography: A Pilot Prospective Randomized Study in Neurocritical Care

Acronym: N-LAT-EIT

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Jan 21, 2020
Registry last updated
Apr 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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