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Completed

NCT Number: NCT02027415

The Effect of Juice Types on the Responses to Air Pollution

The study hypothesis is that drinking different juices will affect the body's responses to air pollution. Subjects will be exposed to air pollution during a 2-hour car ride on the NJ (New Jersey) Turnpike. Each subject will be asked to do this twice. Before one car ride, the subject will be asked to drink orange juice. Before the other car ride, the subject will be asked to drink beet juice. Samples of blood and exhaled breath will be collected before, immediately after, and 24 hours after each car ride. Levels of nitrites/nitrates will be measured in the blood and breath.

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Key information

Conditions

Air Pollution

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Environmental and Occupational Health Sciences Institute

Piscataway, New Jersey, 08854, United States

About this study

Subjects will participate in two exposure sessions. The air pollution exposure consists of a 2-hour car ride along the NJ Turnpike. Samples will be collected at 3 time points for each exposure session: pre-exposure, immediately post-exposure, and 24 hours post-exposure. Blood samples will be collected immediately before and after a 5-minute occlusion at each time point. The subject will also be asked to provide samples of exhaled breath and complete symptom and stress questionnaires at each time point.

Blood samples will be analyzed for serum nitrite. Exhaled breath samples will be analyzed for nitrates and nitrites.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Must live within 20 miles of Piscataway, NJ

Exclusion criteria

  • • Are a current smoker
  • Are pregnant or breastfeeding
  • Are HIV-positive
  • Have an active medical condition such as high blood pressure, asthma, diabetes or other serious disease
  • Have a heart condition such as atrial flutter, atrial fibrillation or a pacemaker
  • Are unable to ride comfortably in a car for 2 hours
  • Travel to the EOHSI (Environmental and Occupational Health Sciences Institute) Clinic Center on major highways for more than 3 miles (the Garden State Parkway, the New Jersey Turnpike, Routes 287, 1, 18, or 9).

Treatment and study plan

Beet Juice

Dietary Supplement

2 cups of beet juice will be given before the car ride

Orange Juice

Dietary Supplement

2 cups of orange juice will be given before the car ride

Primary outcomes

  1. Change in plasma nitrite concentration

    Time frame: Prior to the car ride, immediately after the 2-hour car ride, and 24 hours later

    Change in plasma nitrite concentration pre- and post-occlusion

Secondary outcomes

  1. Change in nitrite/nitrate concentration in exhaled breath

    Time frame: Prior to the car ride, immediately after the 2 hour car ride and 24 hours later

    Change in nitrite/nitrate concentration in exhaled breath

Sponsors and collaborators

Lead sponsor

Rutgers, The State University of New Jersey

Other

Registry information

Official study title

Effects of Oral Nitrate Supplementation on Vascular and Pulmonary Oxidative Stress Markers Following Traffic Pollution Exposure

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Jan 6, 2014
Registry last updated
Dec 13, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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