The Effect of Intravitreal Avastin on the Retina Measured by Electroretinogram

The study will include 20 patients who are diagnosed with CNV and were submitted for intravitreal injection of avastin. Patients with uncontrolled glaucoma, any ocular operation two months prior to the injection, ocular inflammatory disease, systemic hypertension treated with more than one medication, myocardial infarct, congestive heart disease will not be included in the study. After the patient will approve to participate in the study and will fall in with the inclusion and exclusion criteria, the patient will sign a written consent statement (enclosed).

Medical history and ophthalmic examination will be written in the study file. The patients will undergo the full-field ERG test using the ISCEV Protocol. Since the ERG is a non invasive test the patient will be admitted on the same day for intravitreal avastin in the designated eye. After one month the patient will undergo identical ERG protocol in addition to the standard follow-up examinations protocol for intravitreal avastin injection (1 day, 1 week, 1 month). The other eye will serve as control group.

Inclusion criteria

• Patients who were diagnosed with CNV caused by ARMD
• ERG can be performed in both eyes

Exclusion criteria

• Treatment within 7 days with VERTOPROFIN
• Treatment within one month with laser photocoagulation
• Ocular surgery for AMD (besides laser).
• Participation in other medical study
• Sub-fovea RPE atrophy in the study eye.
• CNV with ocular histoplasmosis, trauma, pathological myopia.
• Uveitis or history of uveitis.
• Retinal pigment epithelium tear in the fovea of the injected eye.
• Vitreous hemorrhage
• Conjunctivitis, keratitis, scleritis, endophthalmitis.
• Intraocular surgery (including cataract) within two months
• Uncontrolled glaucoma (IOP≥30 mmHg under glaucoma medications)
• Hypertension treated with two or more medication
• History of myocardial infarct
• History of myocardial insufficiency -