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OpenTrials
Completed

NCT Number: NCT00447239

The Effect of Intensive Insulin Therapy

Aim. To determine whether the maintenance of normoglycemia decreases the incidence of ventilator associated pneumonia (VAP), reduces its treatment period and the length of stay in the intensive care unit.

Methods. Prospective, randomized, controlled trial. We enrolled 117 mechanically ventilated trauma (71) and abdominal (46) surgical patients, older than 18, of both sex. In 57 patients (strict glucose control group) we aimed to maintain the blood glucose level between 4.4 and 6. 1 mmol/L, while in 60 patients (standard glucose control group) it was maintained between 7.8 and 10.0 mmol/L, with the use of continues insulin infusion. Insulin dose adjustments were based on measurements of glucose in capillary blood sample.

Key words: surgical patients; mechanical ventilation; pneumonia; blood glucose; insulin infusion; hospital stay

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Key information

Conditions

the Maintenance of Normoglycemia Infections Lung Diseases Pneumonia Respiratory Tract Diseases Respiratory Tract Infections Treatment Period in the Intensive Care Unit the Incidence of Ventilator Associated Pneumonia (VAP)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Centre Ljubljana

Ljubljana, 1000, Slovenia

About this study

see brief summary

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • surgical patients
  • mechanical ventilated
  • both sex
  • older than 18

Exclusion criteria

  • non-surgical patients
  • non mechanical ventilated
  • younger than 18
  • pregnant women

Treatment and study plan

glucontrol (insulin therapy)

Procedure

Primary outcomes

  1. measurements of glucose in capillary blood sample

Sponsors and collaborators

Lead sponsor

University Medical Centre Ljubljana

Other

Registry information

Official study title

The Effect of Intensive Insulin Therapy on the Incidence of Ventilator-Associated Pneumonia in Surgical Critically Ill Patients

Important dates

Study start
2004
Study completion
2006
First posted
Mar 14, 2007
Registry last updated
Oct 24, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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