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Completed

NCT Number: NCT01899248

The Effect of Inhalation Agent on the QTc Interval During Liver Transplantation: Sub Study (NCT01886664)

The purpose of this study is to assess the effects of inhalation agent on corrected QT interval duration during liver transplantation.

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Key information

Conditions

Anesthesia, General

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • elective liver transplantation

Exclusion criteria

  • age < 18, age > 65
  • patient refusal
  • re-transplantation

Treatment and study plan

Sevoflurane

Drug

Desflurane

Drug

Primary outcomes

  1. corrected QT interval (QTc interval)

    Time frame: up to postoperative day 1 after surgery

    up to 10 minutes after tracheal intubation, up to 60 minutes after reperfusion, at 10 minutes after hepatectomy, at 10 minutes after biliary anastomosis, at skin closure, at the arrival on ICU, on postoperative day 1.

Secondary outcomes

  1. proportion of patients whose QTc interval is more than 450 ms for men and 470 ms for women

    Time frame: up to postoperative day 1 after surgery

  2. proportion of patients who have more than 500 ms of QTc interval

    Time frame: up to postoperative day 1 after surgery

  3. Tp-e interval

    Time frame: up to postoperative day 1 after surgery

    up to 10 minutes after tracheal intubation, up to 60 minutes after reperfusion, at 10 minutes after hepatectomy, at 10 minutes after biliary anastomosis, at skin closure, at the arrival on ICU, on postoperative day 1.

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jul 15, 2013
Registry last updated
May 14, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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