The Effect of Increased Water Intake on the Frequency of the Clinical Recurrent Urinary Tract Infections in Pre-menopausal Women: S-HYDRACYST

This study aims to assess the effect of increased daily water intake on the frequency of clinical, recurrent urinary tract infections (UTI) among low drinking pre-menopausal women suffering from recurrent community-acquired UTI over 12 consecutive months of study product consumption. It is a prospective, single site, open-label, randomised controlled trial in two parallel groups:

• Control group: not changing their fluid intake habits
• Intervention group: provided with mineral water, fluid intake recommendations and regular hydration coaching support

The study population consists in pre-menopausal women diagnosed with recurrent UTIs and having a 'low drinker' profile.

The total number of randomized subjects in this study is estimated at 140. The study will include only women who are low-drinkers (< 1.5 L fluids per day; urinary volume < 1.2 L per day) since they are most likely to have a predisposition to UTIs due to infrequent voiding.

Inclusion criteria

• At least 3 clinical recurrences of symptomatic UTI in the last 12 months
• Age ≥ 18 years

Exclusion criteria

• Incapacity / non-willingness to consume 1.5 L of drinking water per day on top of their usual consumption
• Women with history of UTI complications (pyelonephritis or other) in the last 12 months
• Subjects with interstitial cystitis
• Subjects with severe or uncontrolled organic disease, likely to interfere with the parameters of the study