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Completed

NCT Number: NCT03153436

The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

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Key information

Conditions

Myoinositol Cryopreservation Human Sperm

Age range

20 year–60 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 1 / Phase 2

About this study

Sperm cryopreservation is considered the most valuable and used way to preserve male reproductive function. Unfortunately, osmotic effects of freezing and thawing during the cryopreservation process negatively affect sperm morphology and motility .

Myoinositol is the most biologically important form of inositol in nature. In male reproductive system, myoinositol appears to regulate sperm motility, capacitation and acrosomal reaction.

The objective of this study is to evaluate the effect of in-vitro myoinositol supplementation of human sperm on the outcome of cryopreservation.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Infertile men with normal or abnormal semen analysis

Exclusion criteria

  • Azoospermic samples

Treatment and study plan

Myoinositol

Biological

Primary outcomes

  1. Cryo-survival rate

    Time frame: 7 months

    Post-thawing cryo-survival rates of both aliquots ( myo and control) are compared in both groups (A and B).

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Collaborators

  • Ajyal Hospital

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
May 15, 2017
Registry last updated
May 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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