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Completed

NCT Number: NCT05441007

The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

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Key information

Conditions

Hypoxia Cardiac Output, High Cardiovascular Diseases Heart Diseases Hypercapnia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Czech Technical University in Prague

Kladno, 27201, Czechia

About this study

Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

  • pregnancy
  • severe cardiovascular conditions
  • severe asthma or other severe respiratory conditions
  • injury to the upper limbs or hands that could affect the peripheral perfusion
  • diabetes
  • hypotension or hypertension

Treatment and study plan

Hypoxic

Other

Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.

Hypercapnic

Other

Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.

Hypoxic and Hypercapnic

Other

Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.

Primary outcomes

  1. Changes in Cardiac output due to the induced hypoxia and hypercapnia

    Time frame: 1 hour

    Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change

  2. Changes in Perfusion index due to the induced hypoxia and hypercapnia

    Time frame: 1 hour

    Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change

Sponsors and collaborators

Lead sponsor

Czech Technical University in Prague

Other

Registry information

Official study title

The Effect of Hypercapnia and Hypoxia on Physiological Parameters During Short-term Breathing Experiment

Acronym: HYPERCO

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Jul 1, 2022
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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