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OpenTrials
Completed

NCT Number: NCT01661374

The Effect of Humidification on Mucus Rheology

In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease(COPD) Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Virginia Commonwealth University

Richmond, Virginia, 23284, United States

About this study

Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Mechanically Ventilated Patients

Inclusion criteria

Any Subject Mechanically Ventilated and producing sputum.

Exclusion

  • None

COPD Group

Inclusion criteria

  • 40 to 90 years of age suffering from COPD
  • History of mucus production

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Sputum Collection

    Time frame: 10 minutes

    Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.

Sponsors and collaborators

Lead sponsor

Virginia Commonwealth University

Other

Collaborators

  • Fisher and Paykel Healthcare

Registry information

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Aug 9, 2012
Registry last updated
Dec 10, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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