The Effect of High and Low Roasted Coffee on Vascular Response

Evidence suggests that a diet rich in plant phenolic compounds may induce beneficial vascular effects. Coffee is a good source of phenolic compounds called chlorogenic acids (CGA), however the level of CGA is reduced during the roasting process.

The aim of this study is to investigate the effect of coffee roasting on vascular response. The investigators hypothesize that coffee roasted to a lesser extent will exert a favourable vascular response over more heavily roasted coffee due to the higher levels of CGA.

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Key information

Conditions

Cardiovascular Disease Cardiovascular Diseases

Age range

19 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Food and Nutritional Sciences, Reading, Berkshire, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male
A signed consent form
Age 19-35 years
Body mass index - 18.5-30 kg/m2
Normal blood pressure at screening (< 150/90)

Exclusion criteria

Blood pressure > 150/90 mmHg
Haemoglobin (anaemia marker) < 125 g/l
Gamma GT (liver enzymes) > 80 IU/l
Cholesterol > 6.5 mmol/l
Had suffered a myocardial infarction or stroke in the previous 12 months
Suffers from any reproductive disorder
Suffers from any blood-clotting disorder
Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
Any dietary restrictions or on a weight reducing diet
Drinking more than 21 units per week
On any lipid-modifying medication
On any blood pressure lowering medication
On any medication affecting blood clotting
Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
Regular or vigorous exercise (3 times/week, 20 minutes each session)
Smoking
Vegetarians or vegans

Treatment and study plan

Low roast coffee

Dietary Supplement

Instant coffee

High roast coffee

Dietary Supplement

Instant coffee

Control (Caffeine dissolved in water)

Dietary Supplement

Caffeine dissolved in water

Primary outcomes

Vascular response measured by flow mediated dilatation (FMD)

Time frame: Change from baseline to 2 hours

Sponsors and collaborators

Lead sponsor

University of Reading

Other

Registry information

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2013
First posted: Mar 19, 2013
Registry last updated: Mar 19, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed