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OpenTrials
Completed

NCT Number: NCT03770910

The Effect of GIP(3-30)NH2

Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.

Completed

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Key information

Conditions

Endocrine - Other

Age range

18 year–70 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Metabolic Physiology, Gentofte Municipality, Copenhagen, Denmark

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About this study

Infusion of glucose-dependent insulintropic polypeptide (GIP) receptor antagonist and evaluation of effect of insulin secretion in healthy subjects.

Six study hyperglycemic clamps (10 mmol/l) pr. participant.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • BMI 19-28 kg/m*m
  • Stable body weight

Exclusion criteria

  • Diabetes
  • Anemia
  • First-degree relatives with diabetes

Treatment and study plan

GIP receptor antagonist

Other

GIP receptor antagonist

GIP receptor agonist

Other

GIP(1-42)

Saline

Other

Placebo (vehicle for infusions)

Primary outcomes

  1. Insulin secretion

    Time frame: 8 weeks

    Insulin secretion rates (ISR) calculated from serum levels of C-peptide

Sponsors and collaborators

Lead sponsor

University Hospital, Gentofte, Copenhagen

Other

Collaborators

  • Steno Diabetes Center Copenhagen
  • University of Copenhagen

Registry information

Acronym: GA-10

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Dec 10, 2018
Registry last updated
Mar 26, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.