Skip to main content
OpenTrials
Completed

NCT Number: NCT05409885

The Effect of General and Spinal Anesthesia on Neutrophil-to-lymphocyte Ratio

The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Anesthesia, General Anesthesia, Spinal Umbilical Cord

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation

Antalya, 07100, Turkey (Türkiye)

About this study

This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section.

The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18 - 45 years
  • American Society of Anesthesiology (ASA) II-III
  • elective ceserean surgery

Exclusion criteria

  • declining to give written informed consent
  • under 18 years of age or over 45 years of age
  • factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes
  • history of neurological and/or neuromucular disease
  • cooperation cannot be established
  • emergency surgery

Treatment and study plan

General anesthesia

Other

Evaluate the effects of general anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Spinal anesthesia

Other

Evaluate the effects of spinal anesthesia on NLR, PLR and MPV in patients undergoing cesarean section.

Primary outcomes

  1. neutrophil-to-lymphocyte ratio

    Time frame: within 5 minute, following delivery

    Evaluate the effects of NLR in patients undergoing cesarean section

Secondary outcomes

  1. platelet-to-lymphocyte ratio

    Time frame: within 5 minute, following delivery

    Evaluate the effects of PLR in patients undergoing cesarean section

  2. mean platelet volume

    Time frame: within 5 minute, following delivery

    Evaluate the effects of MPV in patients undergoing cesarean section

  3. Newborn Apgar score 1st minute

    Time frame: 1st minute after birth

    Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)

  4. Newborn Apgar score 5th minute

    Time frame: 5th minute after birth

    Appearance (skin color), Pulse (heart rate), Grimace (reflex irritability), Activity (tone), Respiration. Apgar score at 1st min (0-3: severely depressed, 4-6: moderately depressed, 7-10: excellent condition)

Sponsors and collaborators

Lead sponsor

Antalya Training and Research Hospital

Other Gov

Registry information

Official study title

Comparison of the Effect of General and Spinal Anesthesia on Umbilical Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio and Mean Platelet Volume in Patients Undergoing Cesarean Section

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Jun 8, 2022
Registry last updated
Jul 21, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.