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NCT Number: NCT07252687

The Effect of Gender-affirmative Measures on Breast Perception in Trans Men

Breast dysphoria in transmasculine or genderdiverse individuals is a distinct psychological burden associated with depression, anxiety and suicidality. The aim is to systematically investigate the effect of GAHT (gender-affirming hormone therapy) and mastectomy on this form of dysphoria.

The primary objective of this study is to analyse and investigate the psychological and physical effects of breast development on trans men or genderdiverse individuals.

A secondary objective is to determine the extent to which the stress affects the well-being of trans men depending on the coping strategies used (binding vs. taping).

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Key information

Conditions

Transgender Gender Dysphoria in Adolescents and Adults

Age range

16 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • AFAB (Assigned Female At Birth)
  • before starting GAHT
  • before mastectomy

Exclusion criteria

  • Ongoing GAHT
  • Mastectomy already performed
  • Lack of capacity to give consent
  • Insufficient knowledge of German

Treatment and study plan

quality of life questionnaire- iTransQoL, chest dysphoria measure

Other

Before starting treatment, participants should complete the Chest Dysphoria Measure and iTransQoL questionnaires (=time point 0). The second time point for completing the questionnaires again is 3 months after starting hormone therapy. Subsequently, the questionnaires should be completed a third time after breast-affirming surgery. The final survey takes place two years after time point 0, or 6 months after the previous survey.

Primary outcomes

  1. Chest Dysphoria Measure Score

    Time frame: From enrollment to the end of observation after 2 years

    Chest Dysphoria Measure Score before GAHT, during GAHT, and after mastectomy. Possible chest dysphoria scores range from 0 to 51, with higher scores indicating greater distress.

Study contacts

Contact information is provided by the study sponsor or research team.

Katharina Feil

CONTACT

[email protected]

+4351250423276

Sponsors and collaborators

Lead sponsor

Medical University Innsbruck

Other

Registry information

Official study title

The Effect of Gender-affirmative Measures on Breast Perception in Trans Men (TRANSBREAST) - a Prospective Cohort Study

Acronym: TRANSBREAST

Important dates

Study start
2025
Primary completion
2030
Study completion
2030
First posted
Nov 28, 2025
Registry last updated
Mar 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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