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Completed

NCT Number: NCT03408834

The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese Patients

This study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatin in renal ischemic injury, was used.

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Key information

Conditions

Laparoscopic Colorectal Surgery Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Our object in this study was to find out whether laparoscopic colorectal surgery is detrimental to the kidneys via PVI monitoring. To detect the kidney injury, so-called kidney troponin NGAL ,which gives earlier information than creatine in renal ischemic injury, was used.

Patients undergoing elective laparoscopic colorectal surgery, 18 to 75 years old, planned surgery duration longer than 2 hours, were included in this study. Patients were divided into 2 groups with respect to their fluid resuscitation, Group 1: goal directed fluid therapy via PVI monitoring Group 2: conventional fluid resuscitation. Blood samples were drawn from both groups for NGAL measurement before CO2 insufflation (T0), and at 6th(T1) and 12th(T2) hours after CO2 insufflation. At the end of the surgery, sugammadex was given to all patients for reversal of muscular blockade.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • laparoscopic surgery
  • obese patient

Exclusion criteria

  • patient refusal
  • major comorbidity
  • renal failure
  • diabetes mellitus

Treatment and study plan

pulse variability index

Other

fluid management with pulse variability index or conventional

Other names: conventional

Primary outcomes

  1. Diagnosis of acute kidney injury

    Time frame: postoperative 6 th hour

    following up diagnosis of acute kidney injury

Sponsors and collaborators

Lead sponsor

Ankara University

Other

Registry information

Official study title

The Effect of Fluid Management by Pleth Variability Index on Acute Kidney Injury in Obese

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jan 24, 2018
Registry last updated
Jan 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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