The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Completed

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Key information

Conditions

Muscle Strength

Age range

20 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

aged between 20 to 35 years
healthy
untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion criteria

symptomatic musculoskeletal diseases
history of traumatic injuries to muscles, tendons or joints of the lower extremity
knee joint pain within a month prior to enrollment

Treatment and study plan

Experimental knee pain

Other

Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

Non-painful control injections

Other

Injection of isotonic saline into the infrapatellar fat pad

Primary outcomes

Isokinetic knee muscle strength

Time frame: At baseline and after 8 weeks of exercise

Secondary outcomes

One-leg chair rise

Time frame: At baseline and after 8 weeks of exercise

Sponsors and collaborators

Lead sponsor

Frederiksberg University Hospital

Other

Registry information

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: May 4, 2011
Registry last updated: May 4, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed