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OpenTrials
Completed

NCT Number: NCT02224495

The Effect of Exercise Training on Cardiac Structure and Function

Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease. Other cardiovascular and non-cardiovascular benefits have been reported, namely in glucose metabolism, skeletal muscle function, oxidative stress, vascular function, pulmonary circulation, ischaemia-reperfusion lesion and ventricular remodelling.

However, the benefit of exercise training on systolic and diastolic function is controversial especially after acute myocardial infarction where no longitudinal study has evaluated diastolic function using modern echocardiographic parameters.

The hypothesis is that a structured program of exercise training can improve systolic and diastolic function in patients after myocardial infarction.

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Key information

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Cardiology Department Gaia Hospital Center

Gaia, 4450-189, Portugal

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients one month after myocardial infarction
  • Older 18 years

Exclusion criteria

  • Age above 75 years,
  • Inability to exercise,
  • Hemodinamically significant valvular disease,
  • Moderate to severe chronic lung disease (vital capacity and/or forced expiratory volume in 1 s <80% of age-dependent predicted value),
  • Atrial fibrillation
  • Exercise induced myocardial ischemia
  • Anaemia (haemoglobin <12 g/dl).

Treatment and study plan

Structured Exercise Training

Behavioral

Primary outcomes

  1. Myocardial early diastolic velocity at mitral annulus by tissue Doppler (E' velocity)

    Time frame: 4 months

    Determined by echocardiography; results in cm/s

Secondary outcomes

  1. Ratio between early diastolic filling velocity from mitral inflow and myocardial early diastolic velocity at mitral annulus by tissue Doppler (E/E' ratio)

    Time frame: 4 months

    Determined by echocardiography; no unit (ratio)

  2. Myocardial systolic velocity at mitral annulus by tissue Doppler (S' velocity)

    Time frame: 4 months

    Determined by echocardiography; results in cm/s

  3. Left ventriclular ejection fraction

    Time frame: 4 months

    Determined by echocardiography; results in %

Sponsors and collaborators

Lead sponsor

Gaia Hospital

Other

Collaborators

  • Universidade do Porto

Registry information

Important dates

Study start
2011
Primary completion
2012
Study completion
2013
First posted
Aug 25, 2014
Registry last updated
Aug 25, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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