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NCT Number: NCT05737992

The Effect of Exercise in Water on Functional Fitness in People With Parkinson's Disease

The goal of this clinical trial study is to learn about the effect of aquatic exercise in parkinson's patients. The main questions it aims to answer are:

* What is the effect of exercise in water on balance in parkinson's patients? * What is the effect of exercise in water on muscle strength in parkinson's patients? * What is the effect of exercise in water on flexibility in parkinson's patients? Parkinson's patients in this study will do some functional tests. One group of them will do exercises in water 3 times weekly for 8 weeks.

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Key information

Conditions

Parkinson Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Neurologic Disorder Parkinson Disease Parkinsonian Disorders Synucleinopathies

Age range

45 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Pardis specialized wellness institute

Isfahan, Iran

About this study

Parkinson's disease (PD) is a progressive, neurodegenerative movement disorder characterised by the motor symptoms bradykinesia, tremor, rigidity, and postural instability. These are commonly associated with non-motor disturbances, neurobehavioural symptoms and reduced quality of life.

Exercise is currently recommended as an additional strategy to manage PD-induced disability and is a key component of rehabilitation programs for people with PD.

Aquatic exercise is another form of non-conventional exercise that has been growing in popularity in the context of neurorehabilitation.16 The aquatic setting offers specific mechanical advantages due to the hydrostatic and hydrodynamic principles of buoyancy, viscosity and drag.

Due to its ability to enhance functional mobility whilst also being enjoyable,aquatic exercise has become a very popular form of physical training in the management of neurodegenerative disorders.

Recent studies suggest that high-intensity interval training (HIIT) is promising for promoting neuroplasticity in human PD, with short training time and reduced burden. Biomarkers for neuroplasticity such as brain-derived neurotrophic factor (BDNF) and neurodegeneration (including neurofilament light chain ((NfL) and α-synuclein) may play a role, but their response to HIIT is not well-investigated.

The aims of this study are to investigate the effects of HIIT exercises in water on balance, muscle strength, flexibility and gait speed in PD patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical diagnosis of idiopathic PD, from mild to moderate stages (severity from 1 to 4), according to the original version of the Hoehn & Yahr scale (HY)17, assessed by the neurologist
  • Having medical certificate for performing physical activities and attending heated pools

Exclusion criteria

  • Having another neurological pathology
  • Having limiting orthopedic or heart associated conditions
  • changing physical activities or L-dopa-based drug intake parameters

Treatment and study plan

exercise in water

Other

Participants will do some exercises in water for 30-60 minutes. Exercises will be performed at a moderate exercise intensity (12-14 on the Borg Rate of Perceived (RPE) Scale).

All protocols are tailor-made based on each individual's needs and physical abilities.

Primary outcomes

  1. Rate of changes of Balance

    Time frame: Pre test and posttest (after 8 weeks)

    Balance will be assessed by Berg Balance Scale test

  2. Rate of changes of Flexibility

    Time frame: Pre test and posttest (after 8 weeks)

    Balance will be assessed by Sit & Reach test

  3. Rate of changes of Muscle Strength

    Time frame: Pre test and posttest (after 8 weeks)

    Balance will be assessed by 30 s Sit to Stand test and Arm Curl test

  4. Rate of changes of Gait Speed

    Time frame: Pre test and posttest (after 8 weeks)

    Balance will be assessed by 4-meters gait speed test

Sponsors and collaborators

Lead sponsor

Pardis Specialized Wellness Institute

Other

Registry information

Official study title

The Effect of of High Intensity Interval Training in Water on Functional Fitness in People With Parkinson's Disease: A Randomized Controlled Trial

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Feb 21, 2023
Registry last updated
Feb 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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