the Effect of Environmental Factors on Colorectal Cancer Based on Macrogenomes

The aim of this study is to investigate the effects of environmental factors, such as air pollution, on the occurrence, development and prognosis of colorectal cancer; to identify metabolic markers specific to colorectal cancer patients, which will provide a basis for early diagnosis, early intervention and individualized treatment; and to comprehensively understand the mechanism of the occurrence and development of colorectal cancer by integrating the data of environmental factors and the macro-genome, and to develop new predictive and therapeutic strategies.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Colon Cancer Colonic Diseases Colonic Neoplasms Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Cancer Rectal Diseases Rectal Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18 years old;
Patients diagnosed with colorectal cancer by pathologic biopsy before surgery;
Patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrollment;
Willing to participate in the study and sign an informed consent form. Complete clinical data.

Exclusion criteria

Concurrent primary malignant tumor other than colorectal cancer;
Patients with severe cardiopulmonary insufficiency or other systemic diseases that affect the choice of treatment plan;
Inappropriate for enrollment as assessed by the investigator;
Incomplete clinical data.

Treatment and study plan

Primary outcomes

prognosis

Time frame: From date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first, assessed up to 60 months

Overall survival (OS), from date of diagnosis until the date of death from any cause or or loss to follow-up, whichever came first.

Secondary outcomes

Macrogenomic differences

Time frame: The date of macrogenomic testing, assessed up to 1 week after surgery.

Macrogenomic differences in feces.

Sponsors and collaborators

Lead sponsor

Dong Peng

Other

Registry information

Official study title

A Study of Colorectal Cancer Development and Prognosis Based on Environmental Factors and Macrogenomes

Important dates

Study start: 2024
Primary completion: 2027
Study completion: 2027
First posted: Feb 28, 2025
Registry last updated: Feb 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Active, Not Recruiting