Skip to main content
OpenTrials
Completed

NCT Number: NCT04693806

The Effect of Embryo Culture Under a Continuous CO2 Setting Versus a Sequential CO2 Setting

The purpose of this study is to determine if embryo culture under a single CO2 setting improves blastocyst formation rate.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Reproductive Medicine Associates of New Jersey

Basking Ridge, New Jersey, 07920, United States

About this study

Following enrollment, patients will undergo ovarian stimulation and oocyte retrieval per routine as previously consented to at the clinic. IVF stimulation protocol will be at the discretion of the patient's individual provider, per routine. Intracytoplasmic Sperm Injection (ICSI) will be performed and embryos will be cultured to the blastocyst stage per routine. There are no changes to the embryology care itself, the only difference within the study is the CO2 level within the incubator pending the patient's randomization.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Major Inclusion Criteria for participants:

  • Patients undergoing IVF stimulation cycle with plan for subsequent FET

Major Exclusion Criteria for participants:

  • All patients who do not voluntarily give their written consent for participation
  • Male partner with <100,000 total motile spermatozoa per ejaculate (donor sperm is acceptable)
  • Use of surgical procedures to obtain sperm

Treatment and study plan

Continuous CO2 Level

Other

Embryos will be cultured in a single, continuous CO2 setting

Primary outcomes

  1. blastulation rate

    Time frame: approximately one week

    the number of zygotes that reach the blastocyst stage

Sponsors and collaborators

Lead sponsor

Reproductive Medicine Associates of New Jersey

Other

Registry information

Important dates

Study start
2020
Primary completion
2021
Study completion
2022
First posted
Jan 5, 2021
Registry last updated
May 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.