The Effect of Eggs on Postprandial Metabolism

The objective of this randomized, double-blinded, placebo-controlled, 3-way crossover pilot study is to determine whether eggs can favorably alter biomarkers of postprandial metabolism when included with other cooked breakfast foods typically selected by older Americans.

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Key information

Conditions

Healthy

Age range

50 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

Boston, Massachusetts, 02111, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Men & postmenopausal women, aged 50-70 years
BMI 28-34 kg/m2

Exclusion criteria

Cigarette smoking and/or nicotine replacement use
Individuals taking estrogen
Use of cholesterol-lowering medications
Use of blood pressure-lowering medications
Regular use of any stomach acid-lowering medications or laxatives (including fiber supplements)
Cardiovascular (heart) disease
Gastrointestinal disease
Kidney disease
Endocrine disease: including diabetes, untreated thyroid disease
Rheumatoid arthritis
Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
Systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 95 mmHg
Regular use of oral steroids
Regular daily intake of ≥ 2 alcoholic drinks
Vegetarians
Allergy to eggs
Avoidance and/or intolerance of pork products
No dietary supplements, including those containing any vitamins, minerals,herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission

Treatment and study plan

Eggs

Other

Comparison of a high saturated fat/low fiber meal alone, with eggs, and with a protein/cholesterol matched egg-free pudding

Primary outcomes

Postprandial change in blood glucose concentration compared to placebo

Time frame: 0-4 h

Biomarkers of glucoregulation and insulin sensitivity, inflammation, lipid peroxidation, antioxidant activity, and satiety hormone production will be assessed in blood and urine

Sponsors and collaborators

Lead sponsor

Tufts University

Other

Collaborators

American Egg Board

Registry information

Official study title

The Effect of Eggs on Postprandial Metabolism: A Randomized, Controlled Crossover Pilot Study in Older, Overweight Adults

Important dates

Study start: 2011
Primary completion: 2014
Study completion: 2014
First posted: May 10, 2011
Registry last updated: Nov 19, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed