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Completed

NCT Number: NCT07347327

The Effect of Dual-target tACS Combined With Speech Training on Repetition Disorder After Stroke

This clinical trial aims to study whether dual-target transcranial alternating current stimulation (tACS) applied to the auditory and motor brain region can improve repetition disorder in people with stroke, and to evaluate the safety of tACS. The main goals are to answer the following questions:

1. Can dual-tACS stimulation of the auditory and motor brain area improve repetition functions in people with aphasia after stroke? 2. Can it improve the integration of auditory information and speech motor control during communication?

Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better outcomes in aphasia patients.

Participants will:

1. Receive one extra 20-minute session of either real or sham tACS each day for 10 days 2. Attend clinic visits before and after 10-days stimulation for clinical assessments(WAB) and fNIRS recording related brain activity

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Key information

Conditions

Aphasia Communication Disorders Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Speech Disorders

Age range

30 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Meeting the diagnostic criteria for hemorrhagic or ischemic stroke in the Chinese Guidelines for the Prevention and Treatment of Cerebrovascular Diseases(2nd edition), with the first onset, single hemisphere stroke, and confirmed by CT or MRI,course of diease 1-6 months;
  • Age ranging from 30 to 80 years old;
  • Native language is Mandarin or Cantonese;
  • Right-handed;
  • Diagnosed with aphasia by the Western Aphasia Battery (WAB) scale;
  • Able to cooperate in completing the speech repetition test;
  • Normal hearing.

Exclusion criteria

  • Currently receiving non-invasive brain stimulation treatment;
  • Lesions involving the Broca or STG brain regions;
  • History of epilepsy, mental illness,or other neurological or mental disorders;
  • Any contraindications for transcranial electrical stimulation.

Treatment and study plan

Speech Training

Behavioral

speech training(especially repetition training) synchronized with tACS stimulation

real tACS

Other

dual-target tACS on auditory and motor brain area at a frequency of 8 Hz,with individualized current intensity, delivered for 20 minutes.

sham tACS

Other

except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in real group.

Primary outcomes

  1. Western Aphasia Battery (WAB) score

    Time frame: Baseline and 10-days

    Western Aphasia Battery (WAB) score：0-100，higher score means better language function

Sponsors and collaborators

Lead sponsor

Ke Dong, MD

Other

Registry information

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Jan 16, 2026
Registry last updated
Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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