The Effect of Different Dosages of Solute Clearance on Outcome in Twice Weekly Hemodialysis Patients

This is a prospective, randomized, multi-center intervention study. 400 maintenance hemodialysis patients with twice dialysis sessions per week will be enrolled into the study. All the patients have their baseline Kt/V between 1.2 and 1.7 (1.2 ≤ Kt/V < 1.7). After treatment intervention, the patients will be randomized to two groups according to their different Kt/V (1.2 ≤ Kt/V < 1.7 vs. Kt/V ≥ 1.7), then the patients will be regularly followed up at baseline, 12 weeks, 24 weeks, 48 weeks, 72 weeks and 96 weeks. Clinical outcomes such as mortality, complications and life quality between the two groups will be investigated.

Inclusion criteria

• Patients undergoing maintenance hemodialysis for more than 12 weeks were included in the study.
• The patients have their dialysis sessions twice weekly and have baseline Kt/V between 1.2 and 1.7 (1.2 ≤ Kt/V < 1.7).
• Age from 18 to 80, male or female.
• Patients have long term vascular access.

Exclusion criteria

• Patients with an expected survival less than 12 months.
• Without informed consent.
• Unstable organ disease such as uncurable cancer,active inflammation disease and mental disease.
• Patients with an expected follow up less than 48 weeks,such as planned kidney transplant.
• Other conditions regarded as unsuitability by investigator, such as pregnancy, alcohol or drug indulgence. A dry weight more than 90 kg is also excluded in the study.