Completed

NCT Number: NCT02284672

The Effect of Dexmedetomidine on Propofol Requirement for Insertion of Laryngeal Mask Airway

Propofol frequently used as an inducting medication for insertion Laryngeal mask airway(LMA). But propofol alone can be not sufficient for inhibiting upper airway reflex and also result in cardiovascular suppression under enough amount. Dexmedetomidine is a selective alplh2 receptor agonist with analgesic and sedative effects but sparing respiratory function. Therefore propofol combined with dexmedetomidine induction could be more effective in preserve respiration under same condition for LMA insertion than propofol alone. In this study, the investigators investigate the clinical dose of propofol for LMA insertion with premedication of dexmedetomidine, and evaluate the effect of dexmedetomidine.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Precedex Effect to Propofol Requirement

Age range

19 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Jiyoung Yoo

Suweon, Kyunggido, 443-380, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients for surgery not exceed more than 2 hours requiring general anesthesia

Exclusion criteria

history of gastroesophageal reflux High grade obesity Predicted diffiicult airway

Treatment and study plan

Dexmedetomidine

Drug

normal saline

Drug

Primary outcomes

Fail or success for Laryngeal Mask Airway (LMA) insertion

Time frame: During inserting LMA and up to 5 seconds after LMA inserion

Failure for LMA insertion is defined if there is a difficulty for mouth opening or active movement of four limbs or head. Success is smooth LMA insertion without any movement

Sponsors and collaborators

Lead sponsor

Ajou University School of Medicine

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2016
Study completion: 2016
First posted: Nov 6, 2014
Registry last updated: Feb 29, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.