The Effect of Detrusor Underactivity in Determining Outcomes After Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia

The aim of this clinical trial is to evaluate the effect of detrusor underactivity on the functional and symptomatic outcomes following transurethral resection of the prostate (TURP) in benign prostatic hyperplasia patients presenting with chronic urinary retention.

The main questions it aims to answer are:

Will they restore spontaneous voiding?

They will be divided into 2 comparative groups (each group 45 patients) based on detrusor contractility.

* Group (A) consists of patients with normal detrusor (bladder contractility index more than 100). * Group (B) consists of patients with underactive detrusor (bladder contractility index less than 100).

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Key information

Conditions

Detrusor Underactivity Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Lower Urinary Tract Symptoms Male Urogenital Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Transurethral Resection of the Prostate (TURP) Urinary Bladder Diseases Urinary Bladder, Underactive Urogenital Diseases Urologic Diseases Urological Manifestations

Age range

50 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age: more than 50-year-old
Chronic urinary retention secondary to BPH
Prostate size Above 30 and less than 100gm

Exclusion criteria

Prostate size over 100 gm and less than 30 gm
Prostatic carcinoma
Urinary bladder carcinoma
Acute urinary retention
Urethral stricture.
Previous bladder, urethral or prostate surgery.
Acute urinary tract infection.
Neurogenic bladder

Treatment and study plan

Transurethral Resection of Prostate

Procedure

Standard TURP

Primary outcomes

Restore spontaneous voiding

Time frame: 3 months

All the included patients in this study are urethral catheter-dependant pre-operatively and have very bad voiding parameters. we will assess how they will benefit after TURP by regaining spontaneous voiding without the need for urethral catheters any more.

Secondary outcomes

Flow rate improvement

Time frame: 3 months

uroflowmetry will be done to all patients 3 months post operative and results will be compared
Post voiding residual urine volume decrease

Time frame: 3 months

Post voiding residual urine volume will be calculated using ultrasound and results will be compared

Study contacts

Contact information is provided by the study sponsor or research team.

Samir Sherif Rizkallah, MBBCH

CONTACT

[email protected]

+201226846005

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: May 19, 2026
Registry last updated: May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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